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Combating immunosuppression in glioma.

Publication ,  Journal Article
Vega, EA; Graner, MW; Sampson, JH
Published in: Future Oncol
June 2008

Despite maximal therapy, malignant gliomas have a very poor prognosis. Patients with glioma express significant immune defects, including CD4 lymphopenia, increased fractions of regulatory T cells in peripheral blood and shifts in cytokine profiles from Th1 to Th2. Recent studies have focused on ways to combat immunosuppression in patients with glioma as well as in animal models for glioma. We concentrate on two specific ways to combat immunosuppression: inhibition of TGF-beta signaling and modulation of regulatory T cells. TGF-beta signaling can be interrupted by antisense oligonucleotide technology, TGF-beta receptor I kinase inhibitors, soluble TGF-beta receptors and antibodies against TGF-beta. Regulatory T cells have been targeted with antibodies against T-cell markers, such as CD25, CTLA-4 and GITR. In addition, vaccination against Foxp3 has been explored. The results of these studies have been encouraging; combating immunosuppression may be one key to improving prognosis in malignant glioma.

Duke Scholars

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Published In

Future Oncol

DOI

EISSN

1744-8301

Publication Date

June 2008

Volume

4

Issue

3

Start / End Page

433 / 442

Location

England

Related Subject Headings

  • T-Lymphocytes, Regulatory
  • Oncology & Carcinogenesis
  • Immunosuppression Therapy
  • Humans
  • Glioma
  • Brain Neoplasms
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

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Vega, E. A., Graner, M. W., & Sampson, J. H. (2008). Combating immunosuppression in glioma. Future Oncol, 4(3), 433–442. https://doi.org/10.2217/14796694.4.3.433
Vega, Eleanor A., Michael W. Graner, and John H. Sampson. “Combating immunosuppression in glioma.Future Oncol 4, no. 3 (June 2008): 433–42. https://doi.org/10.2217/14796694.4.3.433.
Vega EA, Graner MW, Sampson JH. Combating immunosuppression in glioma. Future Oncol. 2008 Jun;4(3):433–42.
Vega, Eleanor A., et al. “Combating immunosuppression in glioma.Future Oncol, vol. 4, no. 3, June 2008, pp. 433–42. Pubmed, doi:10.2217/14796694.4.3.433.
Vega EA, Graner MW, Sampson JH. Combating immunosuppression in glioma. Future Oncol. 2008 Jun;4(3):433–442.
Journal cover image

Published In

Future Oncol

DOI

EISSN

1744-8301

Publication Date

June 2008

Volume

4

Issue

3

Start / End Page

433 / 442

Location

England

Related Subject Headings

  • T-Lymphocytes, Regulatory
  • Oncology & Carcinogenesis
  • Immunosuppression Therapy
  • Humans
  • Glioma
  • Brain Neoplasms
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis