Apolipoprotein E epsilon 4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases.

Journal Article (Journal Article)

The frequency of the allele for apolipoprotein E type 4 (epsilon 4) is increased in late-onset familial and sporadic Alzheimer's disease (AD). We have examined epsilon 4 frequencies in four distinct, normal, elderly control groups and, most importantly, in patients with amyloid-forming diseases whose epsilon 4 distributions were not previously known (Creutzfeldt-Jakob disease, familial amyloidotic polyneuropathy, Down's syndrome). There were no differences between any of these controls and published control series, cementing the relevance of epsilon 4 for late-onset AD. The increase in late-onset AD was confirmed in two new series.

Full Text

Duke Authors

Cited Authors

  • Saunders, AM; Schmader, K; Breitner, JC; Benson, MD; Brown, WT; Goldfarb, L; Goldgaber, D; Manwaring, MG; Szymanski, MH; McCown, N

Published Date

  • September 1993

Published In

Volume / Issue

  • 342 / 8873

Start / End Page

  • 710 - 711

PubMed ID

  • 8103823

Electronic International Standard Serial Number (EISSN)

  • 1474-547X

International Standard Serial Number (ISSN)

  • 0140-6736

Digital Object Identifier (DOI)

  • 10.1016/0140-6736(93)91709-u


  • eng