Four cardiac hormones increase circulating concentrations of luteinizing hormone and testosterone.

Published

Journal Article

This study was designed to determine whether four peptide hormones consisting of amino acids 1-30-long-acting natriuretic hormone (LANH), 31-67 (vessel dilator), 79-98 (kaliuretic hormone), and 99-126 (atrial natriuretic hormone [ANH])-of the 126 amino acid atrial natriuretic prohormone increase the circulating concentration of testosterone in healthy humans (n = 30). Vessel dilator, kaliuretic hormone, LANH, and ANH increased the circulating concentration of testosterone 3.8, 2.6, 3.9, and 3.4-fold, respectively (p < 0.01 for each), when infused at 100 ng/(kg of body wt . min) for 60 min. The increases in testosterone lasted 2.5-3 h after cessation of the respective atrial natriuretic peptides' infusions. ANH, vessel dilator, LANH, and kaliuretic hormone increased luteinizing hormone (LH) 3-to 8.4-fold (p < 0.001) during infusion, with the maximal increase in LH being 6.7- to 11.7-fold (p < 0.001) secondary to these cardiac hormones. Vessel dilator and kaliuretic hormone increased LH before increasing testosterone in a sequential fashion. These data suggest that four peptide hormones-ANH, LANH, vessel dilator, and kaliuretic hormone-increase the circulating con-centrations of LH and testosterone in humans.

Full Text

Duke Authors

Cited Authors

  • Vesely, DL; San Miguel, GI; Hassan, I; Gower, WR; Schocken, DD

Published Date

  • March 2002

Published In

Volume / Issue

  • 17 / 2

Start / End Page

  • 145 - 150

PubMed ID

  • 12041917

Pubmed Central ID

  • 12041917

International Standard Serial Number (ISSN)

  • 1355-008X

Digital Object Identifier (DOI)

  • 10.1385/ENDO:17:2:145

Language

  • eng

Conference Location

  • United States