Atrial natriuretic peptide increases urodilatin in the circulation.

Journal Article (Journal Article)

BACKGROUND: Urodilatin is a 32-amino-acid (AA) peptide formed in the kidney. METHODS: High-performance gel permeation chromatography and high-pressure liquid chromatography evaluation of plasma followed by sensitive urodilatin and atrial natriuretic peptide (ANP) assays revealed that urodilatin does circulate distinctly from ANP. RESULTS: Urodilatin circulates at very low levels (i.e 9-12 pg/ml). Infusion of ANP increased the circulating concentration of urodilatin 135-fold (p < 0.001), suggesting that some of the effects of ANP may be mediated by urodilatin while long-acting natriuretic peptide, vessel dilator, and kaliuretic peptide did not affect urodilatin in healthy humans (n = 30). Only ANP decreased the renal clearance of urodilatin (60-75%, p < 0.01). Urodilatin was metabolized into peptides smaller than 5 AAs as well as excreted intact into urine. CONCLUSION: Urodilatin circulates and is increased by ANP in humans.

Full Text

Duke Authors

Cited Authors

  • Vesely, DL; Overton, RM; Blankenship, M; McCormick, MT; Schocken, DD

Published Date

  • January 1, 1998

Published In

Volume / Issue

  • 18 / 3

Start / End Page

  • 204 - 213

PubMed ID

  • 9627036

International Standard Serial Number (ISSN)

  • 0250-8095

Digital Object Identifier (DOI)

  • 10.1159/000013338

Language

  • eng

Conference Location

  • Switzerland