Disposition of vessel dilator and long-acting natriuretic peptide in healthy humans after a one-hour infusion.

Journal Article

The present investigation was designed to determine half-lives, distribution phases and metabolic clearance of two new cardiac peptide hormones in humans. Long-acting natriuretic peptide (LANP) and vessel dilator were infused at 100 ng/kg of b.wt./min concentrations for 60 min with their respective concentrations measured by specific radioimmunoassays in plasma during and for 3 hr after infusion. The half-life of vessel dilator was 107 min, whereas the half-life of LANP was 28 min. The average time that the respective peptides were retained in the body (mean residence time) was 214 +/- 34 min for vessel dilator and 178 +/- 12 min for LANP, which indicates that they are widely distributed outside the initial space (i.e., circulation). The metabolic clearance normalized to 1.73 m2 body surface area was 241 ml/min for vessel dilator and 249 ml/min for LANP. The total body clearance normalized to 1.73 m2 body surface area was 130 ml/min for vessel dilator and 293 ml/min for LANP. The significantly (P < .001) longer half-lives and slower metabolic clearance of LANP and vessel dilator compared with atrial natriuretic factor (half-life, 2.5 min, metabolic clearance, 582-2,581 ml/min/1.7 m2) explain why these peptides circulate at concentrations 15- to 24-fold higher than atrial natriuretic factor in healthy humans.

Full Text

Duke Authors

Cited Authors

  • Ackerman, BH; Overton, RM; McCormick, MT; Schocken, DD; Vesely, DL

Published Date

  • August 1997

Published In

Volume / Issue

  • 282 / 2

Start / End Page

  • 603 - 608

PubMed ID

  • 9262321

International Standard Serial Number (ISSN)

  • 0022-3565

Language

  • eng

Conference Location

  • United States