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Atrial natriuretic peptides negatively and positively modulate circulating endothelin in humans.

Publication ,  Journal Article
Vesely, DL; Chiou, S; Douglass, MA; McCormick, MT; Rodriguez-Paz, G; Schocken, DD
Published in: Metabolism
March 1996

The present investigation was designed to examine the effect of four atrial peptide hormones with vasodilatory properties on the circulating immunoreactive (ir) levels of the vasoconstrictive peptide endothelin (ET) in 36 healthy human subjects. Circulating levels of human ET and cyclic guanosine monophosphate ([cGMP], a potential mediator of the effects of atrial peptides), were measured every 30 minutes during 1-hour preinfusion, 1-hour infusion, and 3-hour postinfusion periods. Atrial natriuretic factor ([ANF] amino acid (aa) 99 to 126 of the 126-aa ANF prohormone) and kaliuretic peptide (aa 79 to 98 of this same prohormone) significantly (P<.05) decreased circulating ET concentrations. Kaliuretic peptide effects were early and ANF effects were delayed until kaliuretic peptide effects began to wane. Long-acting natriuretic peptide (LANP), consisting of aa 1 to 30 of the ANF prohormone, on the other hand, significantly (P<.05) increased ET circulating concentrations during a 1-hour infusion period. The increase in ET in the circulation secondary to LANP became nonsignificant, although it was still elevated, within 30 minutes of ceasing LANP infusion. Vessel dilator, consisting of aa 31 to 67 of the ANF prohormone, and infusion of vehicle alone did not significantly change circulating levels of ET during the 5 hours of this investigation. ANF infusion increased plasma cGMP sevenfold, but plasma cGMP had decreased to only onefold above normal during the period that ANF had an effect on circulating ET levels. There was not any significant increase or decrease in plasma cGMP concentrations secondary to the other atrial peptide hormones. These data suggest that kaliuretic peptide and ANF negatively modulate circulating ET concentrations, while LANP, which is released simultaneously with ANF in response to physiologic stimuli, positively modulates circulating ET concentrations to help maintain circulating ET within a narrow normal range. The data from the present investigation would further suggest that circulating cGMP levels do not mediate the various atrial peptide effects on circulating ET levels.

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Published In

Metabolism

DOI

ISSN

0026-0495

Publication Date

March 1996

Volume

45

Issue

3

Start / End Page

315 / 319

Location

United States

Related Subject Headings

  • Middle Aged
  • Male
  • Humans
  • Female
  • Endothelins
  • Endocrinology & Metabolism
  • Cyclic GMP
  • Atrial Natriuretic Factor
  • Adult
  • 3202 Clinical sciences
 

Citation

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Chicago
ICMJE
MLA
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Vesely, D. L., Chiou, S., Douglass, M. A., McCormick, M. T., Rodriguez-Paz, G., & Schocken, D. D. (1996). Atrial natriuretic peptides negatively and positively modulate circulating endothelin in humans. Metabolism, 45(3), 315–319. https://doi.org/10.1016/s0026-0495(96)90284-x
Vesely, D. L., S. Chiou, M. A. Douglass, M. T. McCormick, G. Rodriguez-Paz, and D. D. Schocken. “Atrial natriuretic peptides negatively and positively modulate circulating endothelin in humans.Metabolism 45, no. 3 (March 1996): 315–19. https://doi.org/10.1016/s0026-0495(96)90284-x.
Vesely DL, Chiou S, Douglass MA, McCormick MT, Rodriguez-Paz G, Schocken DD. Atrial natriuretic peptides negatively and positively modulate circulating endothelin in humans. Metabolism. 1996 Mar;45(3):315–9.
Vesely, D. L., et al. “Atrial natriuretic peptides negatively and positively modulate circulating endothelin in humans.Metabolism, vol. 45, no. 3, Mar. 1996, pp. 315–19. Pubmed, doi:10.1016/s0026-0495(96)90284-x.
Vesely DL, Chiou S, Douglass MA, McCormick MT, Rodriguez-Paz G, Schocken DD. Atrial natriuretic peptides negatively and positively modulate circulating endothelin in humans. Metabolism. 1996 Mar;45(3):315–319.
Journal cover image

Published In

Metabolism

DOI

ISSN

0026-0495

Publication Date

March 1996

Volume

45

Issue

3

Start / End Page

315 / 319

Location

United States

Related Subject Headings

  • Middle Aged
  • Male
  • Humans
  • Female
  • Endothelins
  • Endocrinology & Metabolism
  • Cyclic GMP
  • Atrial Natriuretic Factor
  • Adult
  • 3202 Clinical sciences