Weight loss and the heart. Effects of anorexia nervosa and starvation.

Published

Journal Article (Review)

Anorexia nervosa is a common psychiatric disorder predominantly affecting young women, associated with significant morbidity and mortality, much involving the cardiovascular system. In contrast, protein-calorie malnutrition, while not strictly analogous to the protein-sparing characteristics often noted in anorexia nervosa, is a problem of global stature. Physiologic consequences of anorexia nervosa include rhythm disturbances, mitral valve prolapse, plus both systolic and diastolic ventricular dysfunction. Diminished exercise capacity occurs in both states, with marked blunting of the heart rate and blood pressure response. Congestive heart failure may appear, especially during refeeding. In addition to the myofibrillar destruction associated with protein-calorie malnutrition, hypophosphatemia, particularly when exacerbated by unrestricted glucose-rich refeedings or hyperalimentation, may be one additional cause of ventricular dysfunction. A high level of suspicion for cardiovascular complications is, therefore, warranted in the evaluation and therapy of weight loss conditions such as starvation and anorexia nervosa.

Full Text

Duke Authors

Cited Authors

  • Schocken, DD; Holloway, JD; Powers, PS

Published Date

  • April 1989

Published In

Volume / Issue

  • 149 / 4

Start / End Page

  • 877 - 881

PubMed ID

  • 2650647

Pubmed Central ID

  • 2650647

International Standard Serial Number (ISSN)

  • 0003-9926

Language

  • eng

Conference Location

  • United States