Bacterial plasmid partition machinery: a minimalist approach to survival.


Journal Article (Review)

The accurate segregation or partition of replicated DNA is essential for ensuring stable genome transmission. Partition of bacterial plasmids requires only three elements: a centromere-like DNA site and two proteins, a partition NTPase, and a centromere-binding protein (CBP). Because of this simplicity, partition systems have served as tractable model systems to study the fundamental molecular mechanisms required for DNA segregation at an atomic level. In the last few years, great progress has been made in this endeavor. Surprisingly, these studies have revealed that although the basic partition components are functionally conserved between three types of plasmid partition systems, these systems employ distinct mechanisms of DNA segregation. This review summarizes the molecular insights into plasmid segregation that have been achieved through these recent structural studies.

Full Text

Duke Authors

Cited Authors

  • Schumacher, MA

Published Date

  • February 2012

Published In

Volume / Issue

  • 22 / 1

Start / End Page

  • 72 - 79

PubMed ID

  • 22153351

Pubmed Central ID

  • 22153351

Electronic International Standard Serial Number (EISSN)

  • 1879-033X

Digital Object Identifier (DOI)

  • 10.1016/


  • eng

Conference Location

  • England