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Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.

Publication ,  Journal Article
Edwards, TL; Scott, WK; Almonte, C; Burt, A; Powell, EH; Beecham, GW; Wang, L; Züchner, S; Konidari, I; Wang, G; Singer, C; Nahab, F ...
Published in: Ann Hum Genet
March 2010

Parkinson disease (PD) is a chronic neurodegenerative disorder with a cumulative prevalence of greater than one per thousand. To date three independent genome-wide association studies (GWAS) have investigated the genetic susceptibility to PD. These studies implicated several genes as PD risk loci with strong, but not genome-wide significant, associations. In this study, we combined data from two previously published GWAS of Caucasian subjects with our GWAS of 604 cases and 619 controls for a joint analysis with a combined sample size of 1752 cases and 1745 controls. SNPs in SNCA (rs2736990, p-value = 6.7 x 10(-8); genome-wide adjusted p = 0.0109, odds ratio (OR) = 1.29 [95% CI: 1.17-1.42] G vs. A allele, population attributable risk percent (PAR%) = 12%) and the MAPT region (rs11012, p-value = 5.6 x 10(-8); genome-wide adjusted p = 0.0079, OR = 0.70 [95% CI: 0.62-0.79] T vs. C allele, PAR%= 8%) were genome-wide significant. No other SNPs were genome-wide significant in this analysis. This study confirms that SNCA and the MAPT region are major genes whose common variants are influencing risk of PD.

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Published In

Ann Hum Genet

DOI

EISSN

1469-1809

Publication Date

March 2010

Volume

74

Issue

2

Start / End Page

97 / 109

Location

England

Related Subject Headings

  • tau Proteins
  • alpha-Synuclein
  • Polymorphism, Single Nucleotide
  • Parkinson Disease
  • Humans
  • Genome-Wide Association Study
  • Genetics & Heredity
  • 3105 Genetics
  • 1103 Clinical Sciences
 

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Edwards, T. L., Scott, W. K., Almonte, C., Burt, A., Powell, E. H., Beecham, G. W., … Martin, E. R. (2010). Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease. Ann Hum Genet, 74(2), 97–109. https://doi.org/10.1111/j.1469-1809.2009.00560.x
Edwards, Todd L., William K. Scott, Cherylyn Almonte, Amber Burt, Eric H. Powell, Gary W. Beecham, Liyong Wang, et al. “Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.Ann Hum Genet 74, no. 2 (March 2010): 97–109. https://doi.org/10.1111/j.1469-1809.2009.00560.x.
Edwards TL, Scott WK, Almonte C, Burt A, Powell EH, Beecham GW, et al. Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease. Ann Hum Genet. 2010 Mar;74(2):97–109.
Edwards, Todd L., et al. “Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.Ann Hum Genet, vol. 74, no. 2, Mar. 2010, pp. 97–109. Pubmed, doi:10.1111/j.1469-1809.2009.00560.x.
Edwards TL, Scott WK, Almonte C, Burt A, Powell EH, Beecham GW, Wang L, Züchner S, Konidari I, Wang G, Singer C, Nahab F, Scott B, Stajich JM, Pericak-Vance M, Haines J, Vance JM, Martin ER. Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease. Ann Hum Genet. 2010 Mar;74(2):97–109.
Journal cover image

Published In

Ann Hum Genet

DOI

EISSN

1469-1809

Publication Date

March 2010

Volume

74

Issue

2

Start / End Page

97 / 109

Location

England

Related Subject Headings

  • tau Proteins
  • alpha-Synuclein
  • Polymorphism, Single Nucleotide
  • Parkinson Disease
  • Humans
  • Genome-Wide Association Study
  • Genetics & Heredity
  • 3105 Genetics
  • 1103 Clinical Sciences