Pesticide exposure and risk of Parkinson's disease: a family-based case-control study.

Journal Article (Journal Article)

BACKGROUND: Pesticides and correlated lifestyle factors (e.g., exposure to well-water and farming) are repeatedly reported risk factors for Parkinson's disease (PD), but few family-based studies have examined these relationships. METHODS: Using 319 cases and 296 relative and other controls, associations of direct pesticide application, well-water consumption, and farming residences/occupations with PD were examined using generalized estimating equations while controlling for age-at-examination, sex, cigarette smoking, and caffeine consumption. RESULTS: Overall, individuals with PD were significantly more likely to report direct pesticide application than their unaffected relatives (odds ratio = 1.61; 95% confidence interval, 1.13-2.29). Frequency, duration, and cumulative exposure were also significantly associated with PD in a dose-response pattern (p

Full Text

Duke Authors

Cited Authors

  • Hancock, DB; Martin, ER; Mayhew, GM; Stajich, JM; Jewett, R; Stacy, MA; Scott, BL; Vance, JM; Scott, WK

Published Date

  • March 28, 2008

Published In

Volume / Issue

  • 8 /

Start / End Page

  • 6 -

PubMed ID

  • 18373838

Pubmed Central ID

  • PMC2323015

Electronic International Standard Serial Number (EISSN)

  • 1471-2377

Digital Object Identifier (DOI)

  • 10.1186/1471-2377-8-6


  • eng

Conference Location

  • England