Estrogen production and metabolism in endometriosis.

Published

Journal Article (Review)

Aromatase activity is absent in normal endometrium. In contrast, aromatase is expressed aberrantly in endometriosis, which gives rise to strikingly high levels of aromatase activity in this tissue. Both aromatase expression and activity are stimulated by PGE2. This results in local production of estrogen, which induces PGE2 formation and establishes a positive feedback cycle. Another abnormality in endometriosis, that is, deficient 17beta-HSD type 2 expression, impairs the inactivation of estradiol to estrone. These molecular aberrations collectively favor accumulation of increasing quantities of estradiol and PGE2 in endometriosis. The clinical relevance of these findings was exemplified by the successful treatment of an unusually aggressive case of postmenopausal endometriosis using an aromatase inhibitor.

Full Text

Duke Authors

Cited Authors

  • Bulun, SE; Yang, S; Fang, Z; Gurates, B; Tamura, M; Sebastian, S

Published Date

  • March 2002

Published In

Volume / Issue

  • 955 /

Start / End Page

  • 75 - 85

PubMed ID

  • 11949967

Pubmed Central ID

  • 11949967

International Standard Serial Number (ISSN)

  • 0077-8923

Digital Object Identifier (DOI)

  • 10.1111/j.1749-6632.2002.tb02767.x

Language

  • eng

Conference Location

  • United States