Role of aromatase in endometrial disease.

Published

Journal Article (Review)

Aromatase is the key enzyme for estrogen biosynthesis. It is normally expressed in the human ovary, skin, adipose tissue and brain. Aromatase activity is not detectable in normal endometrium. In contrast, aromatase is expressed aberrantly in endometriosis and is stimulated by PGE2. This results in local production of estrogen, which induces PGE2 formation and establishes a positive feedback cycle. Another abnormality in endometriosis, i.e. deficient 17beta-hydroxysteroid dehydrogenase (17beta-HSD) type 2 expression, impairs the inactivation of estradiol to estrone. These molecular aberrations collectively favor accumulation of increasing quantities of estradiol and PGE2 in endometriosis. The clinical relevance of these findings was exemplified by the successful treatment of an unusually aggressive case of post-menopausal endometriosis using an aromatase inhibitor.

Full Text

Duke Authors

Cited Authors

  • Bulun, SE; Yang, S; Fang, Z; Gurates, B; Tamura, M; Zhou, J; Sebastian, S

Published Date

  • December 2001

Published In

Volume / Issue

  • 79 / 1-5

Start / End Page

  • 19 - 25

PubMed ID

  • 11850203

Pubmed Central ID

  • 11850203

International Standard Serial Number (ISSN)

  • 0960-0760

Language

  • eng

Conference Location

  • England