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Stage I, grade 3 endometrioid adenocarcinoma of the endometrium: an analysis of clinical outcomes and patterns of recurrence.

Publication ,  Journal Article
Rasool, N; Fader, AN; Seamon, L; Neubauer, NL; Shahin, FA; Alexander, HA; Moore, K; Moxley, K; Secord, AA; Kunos, C; Rose, PG; O'Malley, DM
Published in: Gynecol Oncol
January 2010

OBJECTIVE: To study patterns of recurrence and survival outcomes in patients with surgical stage I, grade 3 endometrioid adenocarcinoma of the endometrium (EA) treated with various treatment modalities. METHODS: A retrospective multi-institutional study of surgical stage I, grade 3 EA patients diagnosed between 1988 and 2006 was performed. Demographic, clinicopathologic, treatment and outcome data were collected. After surgery, patients were treated with either observation or radiotherapy (vaginal brachytherapy, whole pelvic or both). RESULTS: One hundred seventy-six patients were collected with a median age of 68 years. Twenty-six (15%) were stage IA, 96 (54%) IB and 54 (31%) IC. Sixty-one patients (35%) had lymphovascular space invasion (LVSI) and a mean of 18.9 lymph nodes (LNs) was removed. Seventy-eight patients (44%) were observed while 98 (56%) were treated with radiotherapy, the majority (n=51) receiving brachytherapy. After a median follow-up of 58 months, 20 recurrences (11%) were noted. Ninety percent of recurrences occurred in Stage IB/IC patients. The median time to recurrence was 22.5 months (5-74.5) and 80% of recurrences were extra-pelvic. There was no significant difference in recurrence based upon treatment modality or LVSI. Majority of recurrences were not salvaged as 75% (12/16) died of their disease with a median time of recurrence to death of 8 months. CONCLUSIONS: Patients with stage IB/IC, grade 3 endometrioid adenocarcinoma have a significant risk for extra-pelvic recurrence. Most patients will not be salvaged and will succumb to their disease, suggesting that current loco-regional adjuvant treatment strategies are not optimal and evaluation of more systemic therapies is warranted.

Duke Scholars

Published In

Gynecol Oncol

DOI

EISSN

1095-6859

Publication Date

January 2010

Volume

116

Issue

1

Start / End Page

10 / 14

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Retrospective Studies
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Humans
  • Female
  • Endometrial Neoplasms
  • Disease-Free Survival
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Rasool, N., Fader, A. N., Seamon, L., Neubauer, N. L., Shahin, F. A., Alexander, H. A., … O’Malley, D. M. (2010). Stage I, grade 3 endometrioid adenocarcinoma of the endometrium: an analysis of clinical outcomes and patterns of recurrence. Gynecol Oncol, 116(1), 10–14. https://doi.org/10.1016/j.ygyno.2009.10.043
Rasool, Nabila, Amanda Nickles Fader, Leigh Seamon, Nikki L. Neubauer, Fadi Abu Shahin, Heather A. Alexander, Kathleen Moore, et al. “Stage I, grade 3 endometrioid adenocarcinoma of the endometrium: an analysis of clinical outcomes and patterns of recurrence.Gynecol Oncol 116, no. 1 (January 2010): 10–14. https://doi.org/10.1016/j.ygyno.2009.10.043.
Rasool N, Fader AN, Seamon L, Neubauer NL, Shahin FA, Alexander HA, et al. Stage I, grade 3 endometrioid adenocarcinoma of the endometrium: an analysis of clinical outcomes and patterns of recurrence. Gynecol Oncol. 2010 Jan;116(1):10–4.
Rasool, Nabila, et al. “Stage I, grade 3 endometrioid adenocarcinoma of the endometrium: an analysis of clinical outcomes and patterns of recurrence.Gynecol Oncol, vol. 116, no. 1, Jan. 2010, pp. 10–14. Pubmed, doi:10.1016/j.ygyno.2009.10.043.
Rasool N, Fader AN, Seamon L, Neubauer NL, Shahin FA, Alexander HA, Moore K, Moxley K, Secord AA, Kunos C, Rose PG, O’Malley DM. Stage I, grade 3 endometrioid adenocarcinoma of the endometrium: an analysis of clinical outcomes and patterns of recurrence. Gynecol Oncol. 2010 Jan;116(1):10–14.
Journal cover image

Published In

Gynecol Oncol

DOI

EISSN

1095-6859

Publication Date

January 2010

Volume

116

Issue

1

Start / End Page

10 / 14

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Retrospective Studies
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Humans
  • Female
  • Endometrial Neoplasms
  • Disease-Free Survival