Fiber optic SERS-based plasmonics nanobiosensing in single living cells

Journal Article

We describe the development of small molecule-sensitive plasmonics-active fiber-optic nanoprobes suitable for intracellular bioanalysis in single living human cells using surface-enhanced Raman scattering (SERS) detection. The practical utility of SERS-based fiber-optic nanoprobes is illustrated by measurements of intracellular pH in HMEC-15/hTERT immortalized "normal" human mammary epithelial cells and PC-3 human prostate cancer cells. The results indicate that fiber-optic nanoprobe insertion and interrogation provide a sensitive and selective means to monitor biologically-relevant small molecules at the single cell level. ©2009 SPIE.

Full Text

Duke Authors

Cited Authors

  • Scaffidi, JP; Gregas, MK; Seewaldt, V; Dinh, TV

Published Date

  • September 8, 2009

Published In

Volume / Issue

  • 7312 /

International Standard Serial Number (ISSN)

  • 0277-786X

Digital Object Identifier (DOI)

  • 10.1117/12.824453

Citation Source

  • Scopus