Fiber optic SERS-based plasmonics nanobiosensing in single living cells
Published
Journal Article
We describe the development of small molecule-sensitive plasmonics-active fiber-optic nanoprobes suitable for intracellular bioanalysis in single living human cells using surface-enhanced Raman scattering (SERS) detection. The practical utility of SERS-based fiber-optic nanoprobes is illustrated by measurements of intracellular pH in HMEC-15/hTERT immortalized "normal" human mammary epithelial cells and PC-3 human prostate cancer cells. The results indicate that fiber-optic nanoprobe insertion and interrogation provide a sensitive and selective means to monitor biologically-relevant small molecules at the single cell level. ©2009 SPIE.
Full Text
Duke Authors
Cited Authors
- Scaffidi, JP; Gregas, MK; Seewaldt, V; Dinh, TV
Published Date
- September 8, 2009
Published In
Volume / Issue
- 7312 /
International Standard Serial Number (ISSN)
- 0277-786X
Digital Object Identifier (DOI)
- 10.1117/12.824453
Citation Source
- Scopus