Mimicking maternal smoking and pharmacotherapy of preterm labor: interactions of fetal nicotine and dexamethasone on serotonin and dopamine synaptic function in adolescence and adulthood.
Journal Article (Journal Article)
Fetal coexposure to nicotine and dexamethasone is common: maternal smoking increases the incidence of preterm delivery and glucocorticoids are the consensus treatment for prematurity. We gave pregnant rats 3mg/kg/day of nicotine throughout gestation, a regimen that reproduces smokers' plasma levels, and then on gestational days 17, 18 and 19, we administered 0.2mg/kg of dexamethasone. We evaluated developmental indices for serotonin (5HT) and dopamine synaptic function throughout adolescence, young adulthood and later adulthood, assessing the brain regions possessing major 5HT and dopamine projections and cell bodies. Males displayed persistent upregulation of 5HT(1A) and 5HT(2) receptors and the 5HT transporter, with a distinct hierarchy of effects: nicotine
Full Text
Duke Authors
Cited Authors
- Slotkin, TA; Seidler, FJ
Published Date
- April 29, 2010
Published In
Volume / Issue
- 82 / 1-2
Start / End Page
- 124 - 134
PubMed ID
- 20211707
Electronic International Standard Serial Number (EISSN)
- 1873-2747
Digital Object Identifier (DOI)
- 10.1016/j.brainresbull.2010.02.015
Language
- eng
Conference Location
- United States