Exposure of developing chicks to perfluorooctanoic acid induces defects in prehatch and early posthatch development.

Published

Journal Article

There is increasing concern over the widespread use of perfluorinated chemicals, which accumulate in various tissues and penetrate the mammalian fetus. A chick model was established for the rapid evaluation of teratogenicity of these chemicals, an important issue because developmental defects often occur at lower exposures than those required for adult systemic toxicity. Chicken eggs were injected with varying doses of perfluorooctanoic acid prior to incubation. Observed were defects in hatching, increased incidence of splayed legs, and interference with the appropriate development of yellow plumage. All these defects are potentially related to essential molecular/biochemical and functional development of the chick. Because of the relationship between structural defects and vulnerability of the developing brain, our model points to the need to evaluate neurobehavioral teratogenicity, which may involve even lower doses.

Full Text

Duke Authors

Cited Authors

  • Yanai, J; Dotan, S; Goz, R; Pinkas, A; Seidler, FJ; Slotkin, TA; Zimmerman, F

Published Date

  • 2008

Published In

Volume / Issue

  • 71 / 2

Start / End Page

  • 131 - 133

PubMed ID

  • 18080903

Pubmed Central ID

  • 18080903

International Standard Serial Number (ISSN)

  • 1528-7394

Digital Object Identifier (DOI)

  • 10.1080/15287390701613280

Language

  • eng

Conference Location

  • England