Non-neurogenic stimulation of adrenomedullary secretion during endotoxicosis in the one day old rat.

Journal Article (Journal Article)

In both newborn and twenty day old rats, bacterial (S. enteritidis) endotoxin caused a marked decrease in adrenal epinephrine and norepinephrine. Catecholamine release was prevented by ganglionic blockade in 20 day old, but not 1 day old animals, indicating that the release in the neonatal rat is "non-neurogenic." The amount released was physiologically significant: equivalent to 20 micrograms/kg by i.v. administration. Two possible mechanism known to promote non-neurogenic secretion are hypoxia or histamine release, both of which can occur during endotoxicosis.

Full Text

Duke Authors

Cited Authors

  • Seidler, FJ; Mills, E

Published Date

  • 1989

Published In

Volume / Issue

  • 45 / 5

Start / End Page

  • 379 - 381

PubMed ID

  • 2671564

International Standard Serial Number (ISSN)

  • 0024-3205

Digital Object Identifier (DOI)

  • 10.1016/0024-3205(89)90623-1


  • eng

Conference Location

  • Netherlands