Osteoarthritis-like changes and decreased mechanical function of articular cartilage in the joints of mice with the chondrodysplasia gene (cho).

Journal Academic Article, Research Support, U.S. Gov't, P.H.S.

To investigate whether heterozygosity for a loss-of-function mutation in the gene encoding the alpha1 chain of type XI collagen (Col11a1) in mice (chondrodysplasia, cho) causes osteoarthritis (OA), and to understand the biochemical and biomechanical effects of this mutation on articular cartilage in knee and temporomandibular (TM) joints.

Full Text

Duke Authors

Cited Authors

  • Xu, L; Flahiff, CM; Waldman, BA; Wu, D; Olsen, BR; Setton, LA; Li, Y

Published Date

  • September 2003

Published In

Volume / Issue

  • 48 / 9

Start / End Page

  • 2509 - 2518

PubMed ID

  • 13130470

International Standard Serial Number (ISSN)

  • 0004-3591

Digital Object Identifier (DOI)

  • 10.1002/art.11233

Language

  • eng

Citation Source

  • PubMed