Osteoarthritis-like changes and decreased mechanical function of articular cartilage in the joints of mice with the chondrodysplasia gene (cho).
Journal Academic Article, Research Support, U.S. Gov't, P.H.S.
To investigate whether heterozygosity for a loss-of-function mutation in the gene encoding the alpha1 chain of type XI collagen (Col11a1) in mice (chondrodysplasia, cho) causes osteoarthritis (OA), and to understand the biochemical and biomechanical effects of this mutation on articular cartilage in knee and temporomandibular (TM) joints.
Xu, L; Flahiff, CM; Waldman, BA; Wu, D; Olsen, BR; Setton, LA; Li, Y
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