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From promiscuity to precision: protein phosphatases get a makeover.

Publication ,  Journal Article
Virshup, DM; Shenolikar, S
Published in: Mol Cell
March 13, 2009

The control of biological events requires strict regulation using complex protein phosphorylation and dephosphorylation strategies. The bulk of serine-threonine dephosphorylations are catalyzed by a handful of phosphatase catalytic subunits, giving rise to the misconception that these phosphatases are promiscuous and unregulated enzymes in vivo. The reality is much more nuanced: PP1 and PP2A, the most abundant serine-threonine phosphatases, are, in fact, families of hundreds of protein serine/threonine phosphatases, assembled from a few catalytic subunits in combination with a highly diverse array of regulators. As recent publications illustrate, these regulatory subunits confer specificity, selectivity, localization, and regulation on these important enzymes.

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Published In

Mol Cell

DOI

EISSN

1097-4164

Publication Date

March 13, 2009

Volume

33

Issue

5

Start / End Page

537 / 545

Location

United States

Related Subject Headings

  • tau Proteins
  • Transforming Growth Factor beta
  • Substrate Specificity
  • Signal Transduction
  • Protein Processing, Post-Translational
  • Protein Phosphatase 2
  • Protein Phosphatase 1
  • Protein Conformation
  • Phosphorylation
  • Phosphoprotein Phosphatases
 

Citation

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Virshup, D. M., & Shenolikar, S. (2009). From promiscuity to precision: protein phosphatases get a makeover. Mol Cell, 33(5), 537–545. https://doi.org/10.1016/j.molcel.2009.02.015
Virshup, David M., and Shirish Shenolikar. “From promiscuity to precision: protein phosphatases get a makeover.Mol Cell 33, no. 5 (March 13, 2009): 537–45. https://doi.org/10.1016/j.molcel.2009.02.015.
Virshup DM, Shenolikar S. From promiscuity to precision: protein phosphatases get a makeover. Mol Cell. 2009 Mar 13;33(5):537–45.
Virshup, David M., and Shirish Shenolikar. “From promiscuity to precision: protein phosphatases get a makeover.Mol Cell, vol. 33, no. 5, Mar. 2009, pp. 537–45. Pubmed, doi:10.1016/j.molcel.2009.02.015.
Virshup DM, Shenolikar S. From promiscuity to precision: protein phosphatases get a makeover. Mol Cell. 2009 Mar 13;33(5):537–545.
Journal cover image

Published In

Mol Cell

DOI

EISSN

1097-4164

Publication Date

March 13, 2009

Volume

33

Issue

5

Start / End Page

537 / 545

Location

United States

Related Subject Headings

  • tau Proteins
  • Transforming Growth Factor beta
  • Substrate Specificity
  • Signal Transduction
  • Protein Processing, Post-Translational
  • Protein Phosphatase 2
  • Protein Phosphatase 1
  • Protein Conformation
  • Phosphorylation
  • Phosphoprotein Phosphatases