NHERF and regulation of the renal sodium-hydrogen exchanger NHE3.

Journal Article (Journal Article;Review)

The sodium-hydrogen exchanger 3 (NHE3) isoform is the major regulated sodium transporter in the proximal convoluted tubule of the kidney. Study of the regulation of NHE3 by hormonal stimuli has identified a number of PDZ adaptor proteins that form an apical/subapical membrane scaffold that binds NHE3 and facilitates down-regulation of its activity in response to cAMP and activation of protein kinase A. The precise relation of proximal tubule adaptor proteins such as sodium-hydrogen exchanger regulatory factor-1 (NHERF-1), NHERF-2, and PDZ domain-containing-protein-1 (PDZK1) with each other and with protein targets such as NHE3 has been evolving with the development of specific reagents and genetically altered animals. In this review, we trace the discovery of NHERF-1 and NHERF-2, and update our current understanding of the relation between these proteins and the regulation and trafficking of NHE3.

Full Text

Duke Authors

Cited Authors

  • Weinman, EJ; Cunningham, R; Shenolikar, S

Published Date

  • June 2005

Published In

Volume / Issue

  • 450 / 3

Start / End Page

  • 137 - 144

PubMed ID

  • 15742180

International Standard Serial Number (ISSN)

  • 0031-6768

Digital Object Identifier (DOI)

  • 10.1007/s00424-005-1384-8


  • eng

Conference Location

  • Germany