Irradiation for intimal hyperplasia: implications for peripheral arterial bypass.

Journal Article (Journal Article;Review)

Irradiation has been shown to inhibit postangioplasty intimal hyperplasia ("restenosis") in unbranched tubes. It seems likely that irradiation will similarly be able to inhibit intimal hyperplasia after a surgical anastomosis at a biochemical and cellular level, but whether it will produce a clinically relevant or even clinically detectable difference is unproved. One possibility is that no clinical effect may occur; the search for a "cure" for intimal hyperplasia has been long and, as yet, unsuccessful. On the other hand, if a strong effect without insurmountable logistical problems could be produced, one major cause of bypass graft failure would be preventable. Not only would the incidence of late graft occlusion, need for reoperation, and limb loss be reduced, but, if patency of prosthetics could be sufficiently improved, the initial operation could be made much easier, faster, and perhaps safer.

Full Text

Duke Authors

Cited Authors

  • Illig, KA; Soni, AB; Williams, J; Shortell, CK; Okunieff, P; Schell, M; Rubin, P; Green, RM

Published Date

  • March 2000

Published In

Volume / Issue

  • 190 / 3

Start / End Page

  • 364 - 370

PubMed ID

  • 10703864

International Standard Serial Number (ISSN)

  • 1072-7515

Digital Object Identifier (DOI)

  • 10.1016/s1072-7515(99)00271-9


  • eng

Conference Location

  • United States