Clinical review: irradiation for lower extremity arterial occlusive disease.

Journal Article (Journal Article;Review)

Lower extremity atherosclerosis, a disease of aging, is both widespread and increasing in prevalence-it is estimated that almost 100,000 patients per year in the United States require operative bypass for lower extremity ischemia. It is an axiom of vascular surgery that essentially every bypass graft will eventually fail. Many if not most such failures are due to the process of intimal hyperplasia at one or both anastomoses. The search for a "cure" for intimal hyperplasia has been long, but thus far unrewarding. Recent advances in therapeutic irradiation, however, offer a potential solution to this problem. This review is designed to acquaint the radiation oncologist with the basic concepts behind lower extremity atherosclerosis and its treatment, and to introduce briefly the special problems inherent in considering irradiation of an end-to-side anastomosis.

Full Text

Duke Authors

Cited Authors

  • Illig, KA; Soni, A; Williams, J; Shortell, CK; Green, RM

Published Date

  • 1999

Published In

Volume / Issue

  • 1 / 3

Start / End Page

  • 288 - 296

PubMed ID

  • 11272374

International Standard Serial Number (ISSN)

  • 1522-1865

Digital Object Identifier (DOI)

  • 10.1016/s1522-1865(99)00017-7


  • eng

Conference Location

  • United States