Mechanosensitivity of gramicidin A channels in bulged bilayer membranes at constant tension


Journal Article

Mechanoelectrical transduction in gramicidin A channels was studied in macroscopic planar lipid bilayer membranes bulged at constant tension. We found a supralinear increase in the single channel activity that was proportional to the square of membrane radius, but could not be accounted for by the increase in membrane surface area, or by recruitment of new channels. Extrapolated to biological membranes, these observations may suggest that the permeability of ion channels can be influenced simply by changing shape of the membrane, with or without stretching. © Nauka/Interperiodica 2006.

Full Text

Duke Authors

Cited Authors

  • Markin, VS; Shlyonsky, VG; Simon, SA; Benos, DJ; Ismailov, II

Published Date

  • December 1, 2006

Published In

Volume / Issue

  • 51 / 6

Start / End Page

  • 892 - 895

Electronic International Standard Serial Number (EISSN)

  • 1555-6654

International Standard Serial Number (ISSN)

  • 0006-3509

Digital Object Identifier (DOI)

  • 10.1134/S0006350906060078

Citation Source

  • Scopus