TRPV1b, a functional human vanilloid receptor splice variant.

Published

Journal Article

Transient receptor potential (TRP) genes encode a family of related ion-channel subunits. This family consists of cation-selective, calcium-permeable channels that include a group of vanilloid receptor channels (TRPV) implicated in pain and inflammation. These channels are activated by diverse stimuli, including capsaicin, lipids, membrane deformation, heat, and protons. Six members of the TRPV family have been identified that differ predominantly in their activation properties. However, in neurons, TRPV channels do not account for the observed diversity of responses to activators. By probing human and rat brain cDNA libraries to identify TRPV subunits, we identified a novel human TRPV1 RNA splice variant, TRPV1b, which forms functional ion channels that are activated by temperature (threshold, approximately 47 degrees C), but not by capsaicin or protons. Channels with similar activation properties were found in trigeminal ganglion neurons, suggesting that TRPV1b receptors are expressed in these cells and contribute to thermal nociception.

Full Text

Duke Authors

Cited Authors

  • Lu, G; Henderson, D; Liu, L; Reinhart, PH; Simon, SA

Published Date

  • April 2005

Published In

Volume / Issue

  • 67 / 4

Start / End Page

  • 1119 - 1127

PubMed ID

  • 15644492

Pubmed Central ID

  • 15644492

Electronic International Standard Serial Number (EISSN)

  • 1521-0111

International Standard Serial Number (ISSN)

  • 0026-895X

Digital Object Identifier (DOI)

  • 10.1124/mol.104.009852

Language

  • eng