Capsaicin and nicotine both activate a subset of rat trigeminal ganglion neurons.

Published

Journal Article

Nicotine and capsaicin produce many similar physiological responses that include pain, irritation, and vasodilation. To determine whether neuronal nicotine acetylcholine receptors (nAChR) are present on capsaicin-sensitive neurons, whole cell patch-clamp recordings were performed on rat trigeminal ganglion cells. It was found that approximately 20% of the total number of neurons tested was activated by both 100 microM nicotine and 1 nM capsaicin. Other subsets of neurons were activated by only one of these compounds, whereas a fourth subset was not activated by either compound. At -60 mV, the magnitude of the capsaicin-activated currents was about three times larger than the magnitude of the nicotine-activated currents. The current-voltage relationship of the nAChR exhibited marked rectification, such that for voltages > or = 0 mV the current was essentially zero. In contrast, the current-voltage relationship of the capsaicin-activated current was ohmic from +/- 60 mV. These data indicate the existence of subsets of capsaicin-sensitive afferent neurons.

Full Text

Duke Authors

Cited Authors

  • Liu, L; Simon, SA

Published Date

  • June 1996

Published In

Volume / Issue

  • 270 / 6 Pt 1

Start / End Page

  • C1807 - C1814

PubMed ID

  • 8764165

Pubmed Central ID

  • 8764165

International Standard Serial Number (ISSN)

  • 0002-9513

Digital Object Identifier (DOI)

  • 10.1152/ajpcell.1996.270.6.C1807

Language

  • eng

Conference Location

  • United States