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Transcellular and paracellular pathways in lingual epithelia and their influence in taste transduction.

Publication ,  Journal Article
Simon, SA; Holland, VF; Benos, DJ; Zampighi, GA
Published in: Microsc Res Tech
October 15, 1993

The lingual epithelium is innervated by special sensory (taste) and general sensory (trigeminal) nerves that transmit information about chemical stimuli introduced into the mouth to the higher brain centers. Understanding the cellular mechanisms involved in eliciting responses from these nerves requires a detailed understanding of the contributions of both the paracellular and transcellular pathways. In this paper we focus on the contribution of these 2 pathways to the responses of salts containing sodium and various organic anions in the presence and absence of amiloride. Electrophysiological recordings from trigeminal nerves, chorda tympani nerves, and isolated lingual epithelia were combined with morphological studies investigating the location (and permeability) of tight junctions, the localization of amiloride-inhibitable channels, and Na-K-ATPase in taste and epithelial cells. Based on these measurements, we conclude that diffusion across tight junctions can modulate chorda tympani and trigeminal responses to sodium-containing salts and rationalize the enhancement of taste responses to saccharides by NaCl.

Duke Scholars

Published In

Microsc Res Tech

DOI

ISSN

1059-910X

Publication Date

October 15, 1993

Volume

26

Issue

3

Start / End Page

196 / 208

Location

United States

Related Subject Headings

  • Trigeminal Nerve
  • Tongue
  • Taste
  • Sodium-Potassium-Exchanging ATPase
  • Sodium Channels
  • Signal Transduction
  • Rats, Sprague-Dawley
  • Rats
  • Microscopy
  • Male
 

Citation

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Simon, S. A., Holland, V. F., Benos, D. J., & Zampighi, G. A. (1993). Transcellular and paracellular pathways in lingual epithelia and their influence in taste transduction. Microsc Res Tech, 26(3), 196–208. https://doi.org/10.1002/jemt.1070260303
Simon, S. A., V. F. Holland, D. J. Benos, and G. A. Zampighi. “Transcellular and paracellular pathways in lingual epithelia and their influence in taste transduction.Microsc Res Tech 26, no. 3 (October 15, 1993): 196–208. https://doi.org/10.1002/jemt.1070260303.
Simon SA, Holland VF, Benos DJ, Zampighi GA. Transcellular and paracellular pathways in lingual epithelia and their influence in taste transduction. Microsc Res Tech. 1993 Oct 15;26(3):196–208.
Simon, S. A., et al. “Transcellular and paracellular pathways in lingual epithelia and their influence in taste transduction.Microsc Res Tech, vol. 26, no. 3, Oct. 1993, pp. 196–208. Pubmed, doi:10.1002/jemt.1070260303.
Simon SA, Holland VF, Benos DJ, Zampighi GA. Transcellular and paracellular pathways in lingual epithelia and their influence in taste transduction. Microsc Res Tech. 1993 Oct 15;26(3):196–208.
Journal cover image

Published In

Microsc Res Tech

DOI

ISSN

1059-910X

Publication Date

October 15, 1993

Volume

26

Issue

3

Start / End Page

196 / 208

Location

United States

Related Subject Headings

  • Trigeminal Nerve
  • Tongue
  • Taste
  • Sodium-Potassium-Exchanging ATPase
  • Sodium Channels
  • Signal Transduction
  • Rats, Sprague-Dawley
  • Rats
  • Microscopy
  • Male