Spinal axon regeneration evoked by replacing two growth cone proteins in adult neurons.

Published

Journal Article

In contrast to peripheral nerves, damaged axons in the mammalian brain and spinal cord rarely regenerate. Peripheral nerve injury stimulates neuronal expression of many genes that are not generally induced by CNS lesions, but it is not known which of these genes are required for regeneration. Here we show that co-expressing two major growth cone proteins, GAP-43 and CAP-23, can elicit long axon extension by adult dorsal root ganglion (DRG) neurons in vitro. Moreover, this expression triggers a 60-fold increase in regeneration of DRG axons in adult mice after spinal cord injury in vivo. Replacing key growth cone components, therefore, could be an effective way to stimulate regeneration of CNS axons.

Full Text

Duke Authors

Cited Authors

  • Bomze, HM; Bulsara, KR; Iskandar, BJ; Caroni, P; Skene, JH

Published Date

  • January 2001

Published In

Volume / Issue

  • 4 / 1

Start / End Page

  • 38 - 43

PubMed ID

  • 11135643

Pubmed Central ID

  • 11135643

International Standard Serial Number (ISSN)

  • 1097-6256

Digital Object Identifier (DOI)

  • 10.1038/82881

Language

  • eng

Conference Location

  • United States