Growth-associated proteins and the curious dichotomies of nerve regeneration
The association between axon growth and induction of growth-associated proteins further capitalizes on the advantages of neurons. Specific induction of these GAPs during both developmental and regenerative axon growth suggests that they are more likely to be involved with growth than with other aspects of neuronal differentiation on the one hand or with general cellular responses to trauma on the other. Rapid transport of the GAPs into growing axons suggests their direct involvement with local events at the site of growth after than with other possible regulatory events in the cell body. Defining the regulation and specific functions of GAPs, and determining whether neuronal GAPs are related to proteins mediating aspects of growth in other cells, await probes for the GAPs and their genes.