Effects of verapamil on postextrasystolic potentiation.


Journal Article

To assess the effects of verapamil on postextrasystolic potentiation (PESP), contrast left ventriculography was performed in ten healthy anesthetized dogs before and after the intravenous administration of verapamil, 0.1 mg/kg. During the contrast ventriculography, a single atrial premature stimulus was introduced. Ejection fractions of a control beat and postpremature beat were measured before and after verapamil. Before verapamil, the mean ejection fractions of the control beat and the postpremature beat were 60 +/- 10 percent and 67 +/- 10 percent, respectively (p less than 0.05). Following the administration of verapamil, the mean ejection fraction of the control beat decreased from 60 +/- 10 percent to 55 +/- 11 percent (p less than 0.05). However, the mean ejection fraction of the postpremature beats increased when compared with the control beats following intravenous verapamil (65 +/- 8 percent and 55 +/- 11 percent, respectively; p less than 0.05). These results suggest that PESP is not inhibited by the administration of intravenous verapamil.

Full Text

Duke Authors

Cited Authors

  • Mooss, AN; Hilleman, DE; Rysavy, J; Sketch, MH

Published Date

  • May 1992

Published In

Volume / Issue

  • 101 / 5

Start / End Page

  • 1438 - 1441

PubMed ID

  • 1374699

Pubmed Central ID

  • 1374699

International Standard Serial Number (ISSN)

  • 0012-3692

Digital Object Identifier (DOI)

  • 10.1378/chest.101.5.1438


  • eng

Conference Location

  • United States