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LDH isoenzymes and myocardial infarction in patients undergoing coronary bypass surgery: an excellent correlation.

Publication ,  Journal Article
Mohiuddin, SM; Raffetto, J; Sketch, MH; Lynch, JD; Schultz, RD; Runco, V
Published in: Am Heart J
November 1976

To evaluate the efficacy of LDH isoenzymes in the detection of myocardial infarction in patients undergoing coronary bypass surgery, 73 patients were studied pre- and postoperatively by ECG, CPK, SGOT, total serum LDH, and LDH isoenzyme measurements. A reversal of the LDH1:LDH2 ratio was considered indicative of myocardial necrosis. Accordingly, the patients were separated into two groups: Group A (23 patients) who demonstrated an LDH1:LDH2 ratio exceeding 1.0 and Group B (50 patients) who failed to reveal an LDH1;LDH2 reversal. The two groups were similar in regard to preoperative evaluation and operative procedure performed. The postoperative ECG findings were significantly different. In Group A 18 of 23 patients (78 per cent) developed significant new Q waves. This occurred in only one patient in Group B. Significant arrhythmias occurred in 70 per cent of the patients in Group A as compared to 14 per cent of those patients in Group B. Severe congestive heart failure and/or clinical evidence of shock occurred in 39 per cent of Group A patients and in none in Group B. The results of our study indicate that the reversal of the LDH1:LDH2 ratio is a valuable tool for the evaluation of postoperative myocardial infarction.

Duke Scholars

Published In

Am Heart J

DOI

ISSN

0002-8703

Publication Date

November 1976

Volume

92

Issue

5

Start / End Page

584 / 588

Location

United States

Related Subject Headings

  • Transplantation, Autologous
  • Saphenous Vein
  • Postoperative Complications
  • Necrosis
  • Myocardial Infarction
  • Middle Aged
  • Male
  • L-Lactate Dehydrogenase
  • Isoenzymes
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Mohiuddin, S. M., Raffetto, J., Sketch, M. H., Lynch, J. D., Schultz, R. D., & Runco, V. (1976). LDH isoenzymes and myocardial infarction in patients undergoing coronary bypass surgery: an excellent correlation. Am Heart J, 92(5), 584–588. https://doi.org/10.1016/s0002-8703(76)80077-4
Mohiuddin, S. M., J. Raffetto, M. H. Sketch, J. D. Lynch, R. D. Schultz, and V. Runco. “LDH isoenzymes and myocardial infarction in patients undergoing coronary bypass surgery: an excellent correlation.Am Heart J 92, no. 5 (November 1976): 584–88. https://doi.org/10.1016/s0002-8703(76)80077-4.
Mohiuddin SM, Raffetto J, Sketch MH, Lynch JD, Schultz RD, Runco V. LDH isoenzymes and myocardial infarction in patients undergoing coronary bypass surgery: an excellent correlation. Am Heart J. 1976 Nov;92(5):584–8.
Mohiuddin, S. M., et al. “LDH isoenzymes and myocardial infarction in patients undergoing coronary bypass surgery: an excellent correlation.Am Heart J, vol. 92, no. 5, Nov. 1976, pp. 584–88. Pubmed, doi:10.1016/s0002-8703(76)80077-4.
Mohiuddin SM, Raffetto J, Sketch MH, Lynch JD, Schultz RD, Runco V. LDH isoenzymes and myocardial infarction in patients undergoing coronary bypass surgery: an excellent correlation. Am Heart J. 1976 Nov;92(5):584–588.
Journal cover image

Published In

Am Heart J

DOI

ISSN

0002-8703

Publication Date

November 1976

Volume

92

Issue

5

Start / End Page

584 / 588

Location

United States

Related Subject Headings

  • Transplantation, Autologous
  • Saphenous Vein
  • Postoperative Complications
  • Necrosis
  • Myocardial Infarction
  • Middle Aged
  • Male
  • L-Lactate Dehydrogenase
  • Isoenzymes
  • Humans