The 2.0 A crystal structure of a heterotrimeric G protein.

Journal Article (Journal Article)

The structure of a heterotrimeric G protein reveals the mechanism of the nucleotide-dependent engagement of the alpha and beta gamma subunits that regulates their interaction with receptor and effector molecules. The interaction involves two distinct interfaces and dramatically alters the conformation of the alpha but not of the beta gamma subunits. The location of the known sites for post-translational modification and receptor coupling suggest a plausible orientation with respect to the membrane surface and an activated heptahelical receptor.

Full Text

Duke Authors

Cited Authors

  • Lambright, DG; Sondek, J; Bohm, A; Skiba, NP; Hamm, HE; Sigler, PB

Published Date

  • January 25, 1996

Published In

Volume / Issue

  • 379 / 6563

Start / End Page

  • 311 - 319

PubMed ID

  • 8552184

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/379311a0

Language

  • eng

Conference Location

  • England