The 2.0 A crystal structure of a heterotrimeric G protein.
Publication
, Journal Article
Lambright, DG; Sondek, J; Bohm, A; Skiba, NP; Hamm, HE; Sigler, PB
Published in: Nature
January 25, 1996
The structure of a heterotrimeric G protein reveals the mechanism of the nucleotide-dependent engagement of the alpha and beta gamma subunits that regulates their interaction with receptor and effector molecules. The interaction involves two distinct interfaces and dramatically alters the conformation of the alpha but not of the beta gamma subunits. The location of the known sites for post-translational modification and receptor coupling suggest a plausible orientation with respect to the membrane surface and an activated heptahelical receptor.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Nature
DOI
ISSN
0028-0836
Publication Date
January 25, 1996
Volume
379
Issue
6563
Start / End Page
311 / 319
Location
England
Related Subject Headings
- Sequence Homology, Amino Acid
- Recombinant Proteins
- Receptors, Cell Surface
- Protein Processing, Post-Translational
- Protein Conformation
- Molecular Sequence Data
- Models, Molecular
- Humans
- Guanosine Triphosphate
- General Science & Technology
Citation
APA
Chicago
ICMJE
MLA
NLM
Lambright, D. G., Sondek, J., Bohm, A., Skiba, N. P., Hamm, H. E., & Sigler, P. B. (1996). The 2.0 A crystal structure of a heterotrimeric G protein. Nature, 379(6563), 311–319. https://doi.org/10.1038/379311a0
Lambright, D. G., J. Sondek, A. Bohm, N. P. Skiba, H. E. Hamm, and P. B. Sigler. “The 2.0 A crystal structure of a heterotrimeric G protein.” Nature 379, no. 6563 (January 25, 1996): 311–19. https://doi.org/10.1038/379311a0.
Lambright DG, Sondek J, Bohm A, Skiba NP, Hamm HE, Sigler PB. The 2.0 A crystal structure of a heterotrimeric G protein. Nature. 1996 Jan 25;379(6563):311–9.
Lambright, D. G., et al. “The 2.0 A crystal structure of a heterotrimeric G protein.” Nature, vol. 379, no. 6563, Jan. 1996, pp. 311–19. Pubmed, doi:10.1038/379311a0.
Lambright DG, Sondek J, Bohm A, Skiba NP, Hamm HE, Sigler PB. The 2.0 A crystal structure of a heterotrimeric G protein. Nature. 1996 Jan 25;379(6563):311–319.
Published In
Nature
DOI
ISSN
0028-0836
Publication Date
January 25, 1996
Volume
379
Issue
6563
Start / End Page
311 / 319
Location
England
Related Subject Headings
- Sequence Homology, Amino Acid
- Recombinant Proteins
- Receptors, Cell Surface
- Protein Processing, Post-Translational
- Protein Conformation
- Molecular Sequence Data
- Models, Molecular
- Humans
- Guanosine Triphosphate
- General Science & Technology