The 2.0 A crystal structure of a heterotrimeric G protein.
Journal Article (Journal Article)
The structure of a heterotrimeric G protein reveals the mechanism of the nucleotide-dependent engagement of the alpha and beta gamma subunits that regulates their interaction with receptor and effector molecules. The interaction involves two distinct interfaces and dramatically alters the conformation of the alpha but not of the beta gamma subunits. The location of the known sites for post-translational modification and receptor coupling suggest a plausible orientation with respect to the membrane surface and an activated heptahelical receptor.
Full Text
Duke Authors
Cited Authors
- Lambright, DG; Sondek, J; Bohm, A; Skiba, NP; Hamm, HE; Sigler, PB
Published Date
- January 25, 1996
Published In
Volume / Issue
- 379 / 6563
Start / End Page
- 311 - 319
PubMed ID
- 8552184
International Standard Serial Number (ISSN)
- 0028-0836
Digital Object Identifier (DOI)
- 10.1038/379311a0
Language
- eng
Conference Location
- England