Reversal of chlorpyrifos neurobehavioral teratogenicity in mice by nicotine administration and neural stem cell transplantation.

Journal Article (Journal Article)

Identifying the mechanisms underlying the adverse effects of developmental neurotoxicants enables the design of therapies that can potentially reverse neurobehavioral deficits in adulthood. We administered chlorpyrifos (CPF), a model organophosphate pesticide to pregnant mice and identified visuospatial deficits in adult offspring using performance in the Morris maze. We then evaluated two strategies to reverse the effects, nicotine administration and transplantation of neural stem cells. Daily administration of nicotine prior to behavioral testing did not alter maze performance by itself, but completely reversed the deficits evoked by prenatal CPF exposure. Similarly, control animals grafted with neural stem cells in adolescence did not show any alterations in behavioral performance as adults, but the grafts completely reversed the effects of prenatal CPF treatment. This study thus provides a model for the development and application of both pharmacologic and cell-based therapies to offset the effects of neurobehavioral teratogens.

Full Text

Duke Authors

Cited Authors

  • Billauer-Haimovitch, H; Slotkin, TA; Dotan, S; Langford, R; Pinkas, A; Yanai, J

Published Date

  • December 28, 2009

Published In

Volume / Issue

  • 205 / 2

Start / End Page

  • 499 - 504

PubMed ID

  • 19682500

Pubmed Central ID

  • PMC2782724

Electronic International Standard Serial Number (EISSN)

  • 1872-7549

Digital Object Identifier (DOI)

  • 10.1016/j.bbr.2009.08.006


  • eng

Conference Location

  • Netherlands