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Reversal of chlorpyrifos neurobehavioral teratogenicity in mice by nicotine administration and neural stem cell transplantation.

Publication ,  Journal Article
Billauer-Haimovitch, H; Slotkin, TA; Dotan, S; Langford, R; Pinkas, A; Yanai, J
Published in: Behav Brain Res
December 28, 2009

Identifying the mechanisms underlying the adverse effects of developmental neurotoxicants enables the design of therapies that can potentially reverse neurobehavioral deficits in adulthood. We administered chlorpyrifos (CPF), a model organophosphate pesticide to pregnant mice and identified visuospatial deficits in adult offspring using performance in the Morris maze. We then evaluated two strategies to reverse the effects, nicotine administration and transplantation of neural stem cells. Daily administration of nicotine prior to behavioral testing did not alter maze performance by itself, but completely reversed the deficits evoked by prenatal CPF exposure. Similarly, control animals grafted with neural stem cells in adolescence did not show any alterations in behavioral performance as adults, but the grafts completely reversed the effects of prenatal CPF treatment. This study thus provides a model for the development and application of both pharmacologic and cell-based therapies to offset the effects of neurobehavioral teratogens.

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Published In

Behav Brain Res

DOI

EISSN

1872-7549

Publication Date

December 28, 2009

Volume

205

Issue

2

Start / End Page

499 / 504

Location

Netherlands

Related Subject Headings

  • Stem Cell Transplantation
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Nootropic Agents
  • Nicotine
  • Neurons
  • Neurology & Neurosurgery
  • Mice
  • Maze Learning
  • Male
 

Citation

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Billauer-Haimovitch, H., Slotkin, T. A., Dotan, S., Langford, R., Pinkas, A., & Yanai, J. (2009). Reversal of chlorpyrifos neurobehavioral teratogenicity in mice by nicotine administration and neural stem cell transplantation. Behav Brain Res, 205(2), 499–504. https://doi.org/10.1016/j.bbr.2009.08.006
Billauer-Haimovitch, Hana, Theodore A. Slotkin, Sharon Dotan, Rachel Langford, Adi Pinkas, and Joseph Yanai. “Reversal of chlorpyrifos neurobehavioral teratogenicity in mice by nicotine administration and neural stem cell transplantation.Behav Brain Res 205, no. 2 (December 28, 2009): 499–504. https://doi.org/10.1016/j.bbr.2009.08.006.
Billauer-Haimovitch H, Slotkin TA, Dotan S, Langford R, Pinkas A, Yanai J. Reversal of chlorpyrifos neurobehavioral teratogenicity in mice by nicotine administration and neural stem cell transplantation. Behav Brain Res. 2009 Dec 28;205(2):499–504.
Billauer-Haimovitch, Hana, et al. “Reversal of chlorpyrifos neurobehavioral teratogenicity in mice by nicotine administration and neural stem cell transplantation.Behav Brain Res, vol. 205, no. 2, Dec. 2009, pp. 499–504. Pubmed, doi:10.1016/j.bbr.2009.08.006.
Billauer-Haimovitch H, Slotkin TA, Dotan S, Langford R, Pinkas A, Yanai J. Reversal of chlorpyrifos neurobehavioral teratogenicity in mice by nicotine administration and neural stem cell transplantation. Behav Brain Res. 2009 Dec 28;205(2):499–504.
Journal cover image

Published In

Behav Brain Res

DOI

EISSN

1872-7549

Publication Date

December 28, 2009

Volume

205

Issue

2

Start / End Page

499 / 504

Location

Netherlands

Related Subject Headings

  • Stem Cell Transplantation
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Nootropic Agents
  • Nicotine
  • Neurons
  • Neurology & Neurosurgery
  • Mice
  • Maze Learning
  • Male