Maternal tobacco smoking, nicotine replacement and neurobehavioural development.

Journal Article (Journal Article;Review)

Abstract The adverse effects of prenatal cigarette smoke exposure on human reproductive outcomes are a major scientific and public health concern. In the United States, approximately 25% of women of childbearing age currently smoke cigarettes, and only a small percentage of these individuals quit after learning of their pregnancy. Women interested in smoking cessation during pregnancy have a number of options, including behavioural and pharmacological aids, but nicotine replacement therapy (NRT) is by far the most common approach. While NRT avoids exposure to the myriad compounds present in tobacco smoke, nicotine itself causes damage to the developing nervous system. The purpose of this article is to review the detrimental effects of developmental tobacco smoke exposure on short- and long-term outcomes with particular emphasis on neurobehavioural consequences. In conclusion based on the clear, adverse effects of nicotine on brain development observed in human and animal studies, we suggest that safer alternatives for smoking cessation in pregnancy are badly needed.

Full Text

Duke Authors

Cited Authors

  • Pauly, JR; Slotkin, TA

Published Date

  • October 2008

Published In

Volume / Issue

  • 97 / 10

Start / End Page

  • 1331 - 1337

PubMed ID

  • 18554275

Pubmed Central ID

  • 18554275

International Standard Serial Number (ISSN)

  • 0803-5253

Digital Object Identifier (DOI)

  • 10.1111/j.1651-2227.2008.00852.x


  • eng

Conference Location

  • Norway