Ornithine decarboxylase and polyamines in developing rat brain and heart: Effects of perinatal hypothyroidism.

Journal Article (Journal Article)

Hypothyroidism induced by perinatal administration of propylthiouracil (PTU) had profound effects on growth of the heart, with major organ weight deficits persisting well beyond the termination of drug treatment. These effects were preceded by disruption of the developmental patterns of cardiac ornithine decarboxylase (ODC) and the polyamines, which are thought to be intracellular modulators of cellular maturation. Activity of cardiac ODC was depressed in the PTU-treated group and putrescine and spermidine levels were markedly subnormal. PTU administration also affected brain growth, but much less so than in the heart. The disruption of the brain ODC/polyamine system was also less pronounced, with relatively small degrees of spermidine depletion and a slight elevation of ODC. For both tissues, the biochemical effects of perinatal hypothyroidism were opposite to those found previously for administration of exogenous thyroid hormones. These results support the views that:

Full Text

Duke Authors

Cited Authors

  • Slotkin, TA; Johnson, A; Whitmore, WL; Slepetis, RJ

Published Date

  • 1984

Published In

Volume / Issue

  • 2 / 2

Start / End Page

  • 155 - 161

PubMed ID

  • 24873959

International Standard Serial Number (ISSN)

  • 0736-5748

Digital Object Identifier (DOI)

  • 10.1016/0736-5748(84)90007-8

Language

  • eng

Conference Location

  • United States