Complement activation and cardiac surgery: a novel target for improving outcomes.
Publication
, Other
Stahl, GL; Shernan, SK; Smith, PK; Levy, JH
Published in: Anesth Analg
October 2012
Complement activation and the resulting inflammatory response is an important potential mechanism for multisystem organ injury in cardiac surgery. Novel therapeutic strategies using complement inhibitors may hold promise for improving outcomes for cardiac surgical patients by attenuating complement activation or its biologically active effector molecules. Recent clinical trials evaluating complement inhibitors have provided important data to further delineate the impact of complement activation and its inhibition on clinical outcomes. In this review we examine the role of complement activation and its inhibition as a therapeutic approach in cardiac surgery.
Duke Scholars
Published In
Anesth Analg
DOI
EISSN
1526-7598
Publication Date
October 2012
Volume
115
Issue
4
Start / End Page
759 / 771
Location
United States
Related Subject Headings
- Treatment Outcome
- Signal Transduction
- Inflammation Mediators
- Humans
- Drug Delivery Systems
- Complement Activation
- Cardiovascular Agents
- Cardiac Surgical Procedures
- Animals
- Anesthesiology
Citation
APA
Chicago
ICMJE
MLA
NLM
Stahl, G. L., Shernan, S. K., Smith, P. K., & Levy, J. H. (2012). Complement activation and cardiac surgery: a novel target for improving outcomes. Anesth Analg. United States. https://doi.org/10.1213/ANE.0b013e3182652b7d
Stahl, Gregory L., Stanton K. Shernan, Peter K. Smith, and Jerrold H. Levy. “Complement activation and cardiac surgery: a novel target for improving outcomes.” Anesth Analg, October 2012. https://doi.org/10.1213/ANE.0b013e3182652b7d.
Stahl GL, Shernan SK, Smith PK, Levy JH. Complement activation and cardiac surgery: a novel target for improving outcomes. Vol. 115, Anesth Analg. 2012. p. 759–71.
Stahl, Gregory L., et al. “Complement activation and cardiac surgery: a novel target for improving outcomes.” Anesth Analg, vol. 115, no. 4, Oct. 2012, pp. 759–71. Pubmed, doi:10.1213/ANE.0b013e3182652b7d.
Stahl GL, Shernan SK, Smith PK, Levy JH. Complement activation and cardiac surgery: a novel target for improving outcomes. Anesth Analg. 2012. p. 759–771.
Published In
Anesth Analg
DOI
EISSN
1526-7598
Publication Date
October 2012
Volume
115
Issue
4
Start / End Page
759 / 771
Location
United States
Related Subject Headings
- Treatment Outcome
- Signal Transduction
- Inflammation Mediators
- Humans
- Drug Delivery Systems
- Complement Activation
- Cardiovascular Agents
- Cardiac Surgical Procedures
- Animals
- Anesthesiology