Prospective evaluation of pulmonary artery pressures during pulmonary angiography performed with low-osmolar nonionic contrast media.

Journal Article (Clinical Trial;Journal Article)

PURPOSE: To determine the effects of pulmonary angiography performed with low-osmolar, nonionic contrast media on pulmonary artery pressures. PATIENTS AND METHODS: In a prospective, uncontrolled clinical trial, pulmonary artery pressures (systolic, diastolic, mean) of 116 patients referred for pulmonary angiography were recorded before and 1 and 5 minutes after injection of contrast material. RESULTS: There was a statistically significant rise in systolic, diastolic, and mean pulmonary artery pressure at 1 minute (4.6, 3.4, 4.1 mm Hg, respectively) and 5 minutes (3.8, 2.7, 3.4 mm Hg, respectively) after the initial contrast material injection (P < .05). Increases were smaller with additional injections. Systolic pressure changes at 1 and 5 minutes after the first injection were linearly dependent on the volume of contrast material injected (P < .05). There was no statistically significant difference in the increase in pulmonary artery pressure between patients with pulmonary embolus or pulmonary arterial hypertension and those without. CONCLUSION: There is a small but statistically significant rise in pulmonary artery pressure after injection of low-osmolar, nonionic contrast material for pulmonary angiography; it is unlikely to be of clinical significance.

Full Text

Duke Authors

Cited Authors

  • Smith, TP; Lee, VS; Hudson, ER; Newman, GE; Payne, CS; Suhocki, PV; McDermott, VG; Stackhouse, DJ

Published Date

  • 1996

Published In

Volume / Issue

  • 7 / 2

Start / End Page

  • 207 - 212

PubMed ID

  • 9007799

International Standard Serial Number (ISSN)

  • 1051-0443

Digital Object Identifier (DOI)

  • 10.1016/s1051-0443(96)70763-7


  • eng

Conference Location

  • United States