Effect of antineoplastic agents on smooth muscle cell proliferation in vitro: implications for prevention of restenosis after transluminal angioplasty.

Journal Article (Journal Article)

The effect of several antineoplastic agents on vascular smooth muscle cell proliferation was studied in vitro. Both fluorouracil and cytarabine produced significant concentration-dependent inhibition of smooth muscle cell proliferation in cultured porcine pulmonary artery in vitro, while cyclophosphamide stimulated growth. For fluorouracil, inhibition was near maximal at a concentration of 13.0 microgram/mL and was seen with both coincubation and 2-hour preincubation of fluorouracil with quiescent cells. Fluorouracil is a promising agent for inhibition of intimal proliferation. Further work is warranted to determine its effect in vivo.

Full Text

Duke Authors

Cited Authors

  • Cragg, AH; Stoll, LL; Smith, TP; Berbaum, K

Published Date

  • May 1992

Published In

Volume / Issue

  • 3 / 2

Start / End Page

  • 273 - 277

PubMed ID

  • 1385739

International Standard Serial Number (ISSN)

  • 1051-0443

Digital Object Identifier (DOI)

  • 10.1016/s1051-0443(92)72025-9


  • eng

Conference Location

  • United States