Two urokinase dose regimens in native arterial and graft occlusions: initial results of a prospective, randomized clinical trial.

Journal Article (Clinical Trial;Journal Article)

The effects of two urokinase (UK) dose regimens on lysis time, lytic success, primary clinical success, and frequency of complications of peripheral thrombolysis were compared. Seventy-two intraarterial UK infusions were performed by means of standard catheter-directed infusion techniques in 63 patients with symptomatic peripheral arterial or bypass graft occlusions. Patients were prospectively randomized to high-dose (250,000 U/h for 4 hours and then 125,000 U/h) or low-dose (50,000 U/h) regimens. The mean time to complete lysis was 20.8, 26.0, 16.5, and 18.2 hours for the high-dose artery, low-dose artery, high-dose graft, and low-dose graft groups, respectively (P was not significant). Respective mean infusion durations were 27.1, 35.4, 22.2, and 25.3 hours. Clinical success was achieved in 65%-85% of cases. The frequency of complications was equivalent between groups, except for a higher frequency of minor bleeding complications in the high-dose group. The two urokinase dose regimens studied were equally effective in enabling peripheral thrombolysis.

Full Text

Duke Authors

Cited Authors

  • Cragg, AH; Smith, TP; Corson, JD; Nakagawa, N; Castaneda, F; Kresowik, TF; Sharp, WJ; Shamma, A; Berbaum, KS

Published Date

  • March 1, 1991

Published In

Volume / Issue

  • 178 / 3

Start / End Page

  • 681 - 686

PubMed ID

  • 1994402

International Standard Serial Number (ISSN)

  • 0033-8419

Digital Object Identifier (DOI)

  • 10.1148/radiology.178.3.1994402


  • eng

Conference Location

  • United States