Two urokinase dose regimens in native arterial and graft occlusions: initial results of a prospective, randomized clinical trial.


Journal Article

The effects of two urokinase (UK) dose regimens on lysis time, lytic success, primary clinical success, and frequency of complications of peripheral thrombolysis were compared. Seventy-two intraarterial UK infusions were performed by means of standard catheter-directed infusion techniques in 63 patients with symptomatic peripheral arterial or bypass graft occlusions. Patients were prospectively randomized to high-dose (250,000 U/h for 4 hours and then 125,000 U/h) or low-dose (50,000 U/h) regimens. The mean time to complete lysis was 20.8, 26.0, 16.5, and 18.2 hours for the high-dose artery, low-dose artery, high-dose graft, and low-dose graft groups, respectively (P was not significant). Respective mean infusion durations were 27.1, 35.4, 22.2, and 25.3 hours. Clinical success was achieved in 65%-85% of cases. The frequency of complications was equivalent between groups, except for a higher frequency of minor bleeding complications in the high-dose group. The two urokinase dose regimens studied were equally effective in enabling peripheral thrombolysis.

Full Text

Duke Authors

Cited Authors

  • Cragg, AH; Smith, TP; Corson, JD; Nakagawa, N; Castaneda, F; Kresowik, TF; Sharp, WJ; Shamma, A; Berbaum, KS

Published Date

  • March 1, 1991

Published In

Volume / Issue

  • 178 / 3

Start / End Page

  • 681 - 686

PubMed ID

  • 1994402

Pubmed Central ID

  • 1994402

International Standard Serial Number (ISSN)

  • 0033-8419

Digital Object Identifier (DOI)

  • 10.1148/radiology.178.3.1994402


  • eng

Conference Location

  • United States