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Nephrotoxicity from contrast material in renal insufficiency: ionic versus nonionic agents.

Publication ,  Journal Article
Harris, KG; Smith, TP; Cragg, AH; Lemke, JH
Published in: Radiology
June 1991

Controversy exists over whether use of low-osmolality contrast agents is of any benefit in mitigating the risk of contrast material-induced nephrotoxicity (CN) in patients with impaired renal function. To test this hypothesis, 101 adult inpatients with high serum creatinine levels (range, 1.4-2.4 mg/dL [120-210 mumol/L]) undergoing contrast material-enhanced computed tomography were randomized to receive ionic or nonionic (low-osmolality) contrast agents in a uniform dose. Changes in serum creatinine level at 48 hours were measured. Seven (14%) of the 50 patients receiving ionic contrast media experienced an increase of 25% or more in serum creatinine level. Only one (2%) of the 51 patients receiving nonionic contrast agents experienced such an increase, a statistically significant difference (P less than .05). In the subset of 25 diabetic patients, the difference was of a similar magnitude. These data suggest that ionic contrast media are more likely than nonionic contrast agents to cause mild exacerbation of renal insufficiency when given intravenously. However, there were no cases of clinically important CN in the study.

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Published In

Radiology

DOI

ISSN

0033-8419

Publication Date

June 1991

Volume

179

Issue

3

Start / End Page

849 / 852

Location

United States

Related Subject Headings

  • Prospective Studies
  • Osmolar Concentration
  • Nuclear Medicine & Medical Imaging
  • Male
  • Kidney Diseases
  • Humans
  • Female
  • Diabetes Mellitus
  • Creatinine
  • Contrast Media
 

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Harris, K. G., Smith, T. P., Cragg, A. H., & Lemke, J. H. (1991). Nephrotoxicity from contrast material in renal insufficiency: ionic versus nonionic agents. Radiology, 179(3), 849–852. https://doi.org/10.1148/radiology.179.3.2028004
Harris, K. G., T. P. Smith, A. H. Cragg, and J. H. Lemke. “Nephrotoxicity from contrast material in renal insufficiency: ionic versus nonionic agents.Radiology 179, no. 3 (June 1991): 849–52. https://doi.org/10.1148/radiology.179.3.2028004.
Harris KG, Smith TP, Cragg AH, Lemke JH. Nephrotoxicity from contrast material in renal insufficiency: ionic versus nonionic agents. Radiology. 1991 Jun;179(3):849–52.
Harris, K. G., et al. “Nephrotoxicity from contrast material in renal insufficiency: ionic versus nonionic agents.Radiology, vol. 179, no. 3, June 1991, pp. 849–52. Pubmed, doi:10.1148/radiology.179.3.2028004.
Harris KG, Smith TP, Cragg AH, Lemke JH. Nephrotoxicity from contrast material in renal insufficiency: ionic versus nonionic agents. Radiology. 1991 Jun;179(3):849–852.
Journal cover image

Published In

Radiology

DOI

ISSN

0033-8419

Publication Date

June 1991

Volume

179

Issue

3

Start / End Page

849 / 852

Location

United States

Related Subject Headings

  • Prospective Studies
  • Osmolar Concentration
  • Nuclear Medicine & Medical Imaging
  • Male
  • Kidney Diseases
  • Humans
  • Female
  • Diabetes Mellitus
  • Creatinine
  • Contrast Media