Thermal balloon angioplasty in a canine model: preliminary results.

Published

Journal Article

Preliminary results suggest that thermal balloon angioplasty (BA) may produce plaque welding, decreased elastic recoil, and increased luminal caliber. The authors report results of a simple method of thermal BA in a canine model. Seven mongrel dogs (15-25 kg) underwent conventional BA of each iliac artery with balloons that were 1-2 mm larger than the vessel lumen. The balloons were then perfused with a mixture of saline and contrast material at either 25 degrees C (control) or 100 degrees C for 1 minute. Compared with baseline measurements, thermal BA produced greater lumen enlargement (+16.7%) than control BA (+3.4%) immediately after the procedure (P less than .05). This trend persisted in vessels studied after a delay of 2, 4, or 12 weeks. Histologic sections from specimens studied after a delay demonstrated intimal hyperplasia in both the thermally treated and control arteries. Medial sclerosis was consistently seen in the thermally treated arteries. The authors conclude that thermal BA results in immediate and delayed increases in arterial diameter compared with conventional BA due to decreased elastic recoil and medial sclerosis.

Full Text

Duke Authors

Cited Authors

  • Gleason, T; Cragg, AH; Smith, TP; Landas, SK; De Jong, SC

Published Date

  • November 1990

Published In

Volume / Issue

  • 1 / 1

Start / End Page

  • 121 - 126

PubMed ID

  • 2151968

Pubmed Central ID

  • 2151968

International Standard Serial Number (ISSN)

  • 1051-0443

Language

  • eng

Conference Location

  • United States