Plaque modification with tetracycline: enhanced tissue ablation with the excimer laser.

Published

Journal Article

Tetracycline has been shown to collect selectively in atherosclerotic plaque and is a known photosensitizing agent. To determine if tetracycline enhances the photoablative effects of the ultraviolet xenon-fluorine excimer laser, the authors exposed four cadaveric aortic samples to tetracycline and four to only normal saline. Ninety-three sites in the samples were subjected to laser energy and analyzed with light microscopy for crater depth and width and for degree of thermal injury. Forty-three of the sites were histologically normal, and 50 were atherosclerotic. Crater depth did not differ significantly in atherosclerotic and normal sites not exposed to tetracycline. Atherosclerotic sites exposed to tetracycline showed significantly deeper craters compared with those in normal, exposed sites. The effects of tetracycline exposure and histologic characteristics (normal vs atherosclerotic) on crater width and thermal injury were independent and additive. When the excimer laser is used for treatment, tetracycline can definitely enhance atherosclerotic plaque ablation.

Full Text

Duke Authors

Cited Authors

  • Smith, TP; Cragg, AH; Landas, SK; Berbaum, KS

Published Date

  • March 1, 1990

Published In

Volume / Issue

  • 174 / 3 Pt 2

Start / End Page

  • 1009 - 1011

PubMed ID

  • 2305081

Pubmed Central ID

  • 2305081

International Standard Serial Number (ISSN)

  • 0033-8419

Digital Object Identifier (DOI)

  • 10.1148/radiology.174.3.174-3-1009

Language

  • eng

Conference Location

  • United States