Molecular mechanisms of leukocyte activation by chemoattractants.

Published

Journal Article (Review)

Chemoattractant receptors on leukocytes initiate migratory and cytotoxic activities via GTP-binding proteins. Recent cloning of cDNA encoding the formylpeptide receptor indicates it to be a member of the class of seven membrane spanning domain receptors which couple to G proteins. Leukocyte activation by chemoattractants requires sequential metabolic pathways involving phospholipase C then phospholipase D. Interestingly, the formylpeptide receptor physically associates with both a heterotrimeric G protein and a low molecular mass GTP-binding protein. These multiple GTP-binding proteins may regulate the function of chemoattractant receptors.

Full Text

Duke Authors

Cited Authors

  • Snyderman, R; Didsbury, J

Published Date

  • 1991

Published In

Volume / Issue

  • 35 /

Start / End Page

  • 3 - 8

PubMed ID

  • 1664188

Pubmed Central ID

  • 1664188

International Standard Serial Number (ISSN)

  • 0379-0363

Language

  • eng

Conference Location

  • Switzerland