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Leukocyte activation by chemoattractant receptors: roles of a guanine nucleotide regulatory protein and polyphosphoinositide metabolism.

Publication ,  Journal Article
Snyderman, R; Verghese, MW
Published in: Rev Infect Dis
1987

Chemoattractant receptors on leukocytes are coupled to a guanine nucleotide regulatory (N or G) protein that stimulates a membrane-associated phospholipase C to hydrolyze phosphatidylinositol 4,5-biphosphate. The products of this hydrolysis are inositol 1,4,5-trisphosphate and 1,2-diacylglycerol, which act as second messengers by raising intracellular levels of Ca++ and activating protein kinase C, respectively. These processes promote cellular activation but also initiate reactions that feed back to inhibit the stimulatory pathway.

Duke Scholars

Published In

Rev Infect Dis

DOI

ISSN

0162-0886

Publication Date

1987

Volume

9 Suppl 5

Start / End Page

S562 / S569

Location

United States

Related Subject Headings

  • Type C Phospholipases
  • Receptors, Immunologic
  • Receptors, Formyl Peptide
  • Phosphatidylinositols
  • Phosphatidylinositol Phosphates
  • Phagocytosis
  • Phagocytes
  • N-Formylmethionine Leucyl-Phenylalanine
  • Models, Biological
  • Leukocytes
 

Citation

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Snyderman, R., & Verghese, M. W. (1987). Leukocyte activation by chemoattractant receptors: roles of a guanine nucleotide regulatory protein and polyphosphoinositide metabolism. Rev Infect Dis, 9 Suppl 5, S562–S569. https://doi.org/10.1093/clinids/9.supplement_5.s562
Snyderman, R., and M. W. Verghese. “Leukocyte activation by chemoattractant receptors: roles of a guanine nucleotide regulatory protein and polyphosphoinositide metabolism.Rev Infect Dis 9 Suppl 5 (1987): S562–69. https://doi.org/10.1093/clinids/9.supplement_5.s562.
Snyderman, R., and M. W. Verghese. “Leukocyte activation by chemoattractant receptors: roles of a guanine nucleotide regulatory protein and polyphosphoinositide metabolism.Rev Infect Dis, vol. 9 Suppl 5, 1987, pp. S562–69. Pubmed, doi:10.1093/clinids/9.supplement_5.s562.

Published In

Rev Infect Dis

DOI

ISSN

0162-0886

Publication Date

1987

Volume

9 Suppl 5

Start / End Page

S562 / S569

Location

United States

Related Subject Headings

  • Type C Phospholipases
  • Receptors, Immunologic
  • Receptors, Formyl Peptide
  • Phosphatidylinositols
  • Phosphatidylinositol Phosphates
  • Phagocytosis
  • Phagocytes
  • N-Formylmethionine Leucyl-Phenylalanine
  • Models, Biological
  • Leukocytes