Leukocyte activation by chemoattractant receptors: roles of a guanine nucleotide regulatory protein and polyphosphoinositide metabolism.

Journal Article (Journal Article;Review)

Chemoattractant receptors on leukocytes are coupled to a guanine nucleotide regulatory (N or G) protein that stimulates a membrane-associated phospholipase C to hydrolyze phosphatidylinositol 4,5-biphosphate. The products of this hydrolysis are inositol 1,4,5-trisphosphate and 1,2-diacylglycerol, which act as second messengers by raising intracellular levels of Ca++ and activating protein kinase C, respectively. These processes promote cellular activation but also initiate reactions that feed back to inhibit the stimulatory pathway.

Full Text

Duke Authors

Cited Authors

  • Snyderman, R; Verghese, MW

Published Date

  • 1987

Published In

Volume / Issue

  • 9 Suppl 5 /

Start / End Page

  • S562 - S569

PubMed ID

  • 2825325

International Standard Serial Number (ISSN)

  • 0162-0886

Digital Object Identifier (DOI)

  • 10.1093/clinids/9.supplement_5.s562


  • eng

Conference Location

  • United States