A potential second messenger role for unsaturated fatty acids: activation of Ca2+-dependent protein kinase.

Journal Article (Journal Article)

Arachidonate and other unsaturated long-chain fatty acids were found to activate protein kinase C from human neutrophils. Kinase activation by arachidonate required calcium and was enhanced by diolein but did not require exogenous phosphatidylserine. Submaximal levels of arachidonate also enhanced the affinity of the kinase for calcium during activation by phosphatidylserine. Thus the release of arachidonate, which is triggered in many cell types by ligand-receptor interactions, could play a second messenger role in the regulation of cellular function by activation of protein kinase C.

Full Text

Duke Authors

Cited Authors

  • McPhail, LC; Clayton, CC; Snyderman, R

Published Date

  • May 11, 1984

Published In

Volume / Issue

  • 224 / 4649

Start / End Page

  • 622 - 625

PubMed ID

  • 6231726

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.6231726


  • eng

Conference Location

  • United States