Neisseria meningitidis and Neisseria gonorrhoeae bacteremia associated with C6, C7, or C8 deficiency.

Journal Article (Journal Article)

We summarize data from 24 previously described or newly diagnosed cases of homozygous deficiency of the sixth, seventh, or eighth components of complement. Thirteen of 24 patients had at least one episode, and usually two or more episodes of Neisseria meningitidis or Neisseria gonorrhoeae bacteremia, or both. Deficiency of C6, C7, or C8 is a meaningful risk factor for repeated neisserial bacteremia; conversely, hemolytic complement studies are indicated in patients who develop recurrent neisserial infections. When a person with C6, C7, or C8 deficiency is identified, family members should also be studied.

Full Text

Duke Authors

Cited Authors

  • Petersen, BH; Lee, TJ; Snyderman, R; Brooks, GF

Published Date

  • June 1, 1979

Published In

Volume / Issue

  • 90 / 6

Start / End Page

  • 917 - 920

PubMed ID

  • 109025

International Standard Serial Number (ISSN)

  • 0003-4819

Digital Object Identifier (DOI)

  • 10.7326/0003-4819-90-6-917


  • eng

Conference Location

  • United States