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Calcium influx requirement for human neutrophil chemotaxis: inhibition by lanthanum chloride.

Publication ,  Journal Article
Boucek, MM; Snyderman, R
Published in: Science
September 3, 1976

Calcium fluxes of human neutrophils measured in the presence of chemotactically active serum showed a marked stimulation of calcium-45 uptake from the media. Chemotactically inactive serum did not cause an influx of calcium. The magnitude of the calcium influx due to activated serum is sufficient to trigger contractile systems previously described in muscle cells. Lanthanum chloride inhibited the chemotactic response of human neutrophils to activated serum. Lanthanum in concentrations that suppressed chemotaxis also inhibited the calcium influx caused by activated serum. Lanthanum in concentrations that suppressed chemotaxis also inhibited the calcium influx caused by activated serum. The data support a direct role of calcium influx in chemotaxis of neutrophils.

Duke Scholars

Published In

Science

DOI

ISSN

0036-8075

Publication Date

September 3, 1976

Volume

193

Issue

4256

Start / End Page

905 / 907

Location

United States

Related Subject Headings

  • Neutrophils
  • Lanthanum
  • Humans
  • General Science & Technology
  • Chemotaxis
  • Cell Movement
  • Calcium
  • Biological Transport
 

Citation

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ICMJE
MLA
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Boucek, M. M., & Snyderman, R. (1976). Calcium influx requirement for human neutrophil chemotaxis: inhibition by lanthanum chloride. Science, 193(4256), 905–907. https://doi.org/10.1126/science.948752
Boucek, M. M., and R. Snyderman. “Calcium influx requirement for human neutrophil chemotaxis: inhibition by lanthanum chloride.Science 193, no. 4256 (September 3, 1976): 905–7. https://doi.org/10.1126/science.948752.
Boucek MM, Snyderman R. Calcium influx requirement for human neutrophil chemotaxis: inhibition by lanthanum chloride. Science. 1976 Sep 3;193(4256):905–7.
Boucek, M. M., and R. Snyderman. “Calcium influx requirement for human neutrophil chemotaxis: inhibition by lanthanum chloride.Science, vol. 193, no. 4256, Sept. 1976, pp. 905–07. Pubmed, doi:10.1126/science.948752.
Boucek MM, Snyderman R. Calcium influx requirement for human neutrophil chemotaxis: inhibition by lanthanum chloride. Science. 1976 Sep 3;193(4256):905–907.
Journal cover image

Published In

Science

DOI

ISSN

0036-8075

Publication Date

September 3, 1976

Volume

193

Issue

4256

Start / End Page

905 / 907

Location

United States

Related Subject Headings

  • Neutrophils
  • Lanthanum
  • Humans
  • General Science & Technology
  • Chemotaxis
  • Cell Movement
  • Calcium
  • Biological Transport