Prostaglandins and inflammation: enhancement of monocyte chemotactic responsiveness by prostaglandin E2.
Journal Article (Journal Article)
The effects of prostaglandins on human monocyte chemotaxis were studied in vitro. None of the prostaglandins tested, including members of the A, B, E or F series, were chemotactic for monocytes. Prostaglandin E2 however, enhanced the chemotactic responsiveness of monocytes to complement - activated human serum by almost 200%. The enhancement of chemotaxis was not directly related to the ability of PGE2 to raise intracellular cyclic AMP levels. These studies support a role for prostaglandins as modulators of the inflammatory response.
Full Text
Duke Authors
Cited Authors
- McClatchey, W; Snyderman, R
Published Date
- September 1, 1976
Published In
Volume / Issue
- 12 / 3
Start / End Page
- 415 - 426
PubMed ID
- 184494
Pubmed Central ID
- 184494
International Standard Serial Number (ISSN)
- 0090-6980
Digital Object Identifier (DOI)
- 10.1016/0090-6980(76)90022-8
Language
- eng
Conference Location
- United States