Prostaglandins and inflammation: enhancement of monocyte chemotactic responsiveness by prostaglandin E2.

Journal Article (Journal Article)

The effects of prostaglandins on human monocyte chemotaxis were studied in vitro. None of the prostaglandins tested, including members of the A, B, E or F series, were chemotactic for monocytes. Prostaglandin E2 however, enhanced the chemotactic responsiveness of monocytes to complement - activated human serum by almost 200%. The enhancement of chemotaxis was not directly related to the ability of PGE2 to raise intracellular cyclic AMP levels. These studies support a role for prostaglandins as modulators of the inflammatory response.

Full Text

Duke Authors

Cited Authors

  • McClatchey, W; Snyderman, R

Published Date

  • September 1, 1976

Published In

Volume / Issue

  • 12 / 3

Start / End Page

  • 415 - 426

PubMed ID

  • 184494

International Standard Serial Number (ISSN)

  • 0090-6980

Digital Object Identifier (DOI)

  • 10.1016/0090-6980(76)90022-8

Language

  • eng

Conference Location

  • United States