The chemotactic attraction of human fibroblasts to a lymphocyte-derived factor.

Journal Article (Journal Article)

A quantitative assay that measures fibroblast chemotaxis in vitro is described. Application of this technique has revealed that peripheral blood lymphocytes stimulated by antigen or mitogen in vitro produce a factor that is chemotactic for human dermal fibroblasts. This lymphocyte-derived chemotactic factor for fibroblasts (LDCF-F) is different from the lymphokine that is chemotactic for monocytes or macrophages. Macrophages are required for the generation of LDCF-F by T lymphocytes stimulated by phytohemagglutinin. The fibroblast chemotactic factor is heat stable (56 degrees C for 30 min), trypsin sensitive, and neuraminidase resistant. LDCF-F could function to attact connective tissue fibroblasts to sites at which cell-mediated immune reactions are occurring in vivo.

Full Text

Duke Authors

Cited Authors

  • Postlethwaite, AE; Snyderman, R; Kang, AH

Published Date

  • November 2, 1976

Published In

Volume / Issue

  • 144 / 5

Start / End Page

  • 1188 - 1203

PubMed ID

  • 825607

Pubmed Central ID

  • PMC2190454

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.144.5.1188


  • eng

Conference Location

  • United States