The chemotactic attraction of human fibroblasts to a lymphocyte-derived factor.
Published
Journal Article
A quantitative assay that measures fibroblast chemotaxis in vitro is described. Application of this technique has revealed that peripheral blood lymphocytes stimulated by antigen or mitogen in vitro produce a factor that is chemotactic for human dermal fibroblasts. This lymphocyte-derived chemotactic factor for fibroblasts (LDCF-F) is different from the lymphokine that is chemotactic for monocytes or macrophages. Macrophages are required for the generation of LDCF-F by T lymphocytes stimulated by phytohemagglutinin. The fibroblast chemotactic factor is heat stable (56 degrees C for 30 min), trypsin sensitive, and neuraminidase resistant. LDCF-F could function to attact connective tissue fibroblasts to sites at which cell-mediated immune reactions are occurring in vivo.
Full Text
Duke Authors
Cited Authors
- Postlethwaite, AE; Snyderman, R; Kang, AH
Published Date
- November 2, 1976
Published In
Volume / Issue
- 144 / 5
Start / End Page
- 1188 - 1203
PubMed ID
- 825607
Pubmed Central ID
- 825607
International Standard Serial Number (ISSN)
- 0022-1007
Digital Object Identifier (DOI)
- 10.1084/jem.144.5.1188
Language
- eng
Conference Location
- United States