Depressed monocyte chemotaxis during acute influenza infection.

Journal Article (Journal Article)

The chemotactic responsiveness of monocytes from patients with serologically proven influenza infection has been quantified in vitro. Individuals with acute influenza had a significant (P less than 0-001) depression of monocyte chemotaxis. The depression ranged from 40% to 72% during acute infection but rose to normal by three weeks after recovery. When isolated mononuclear leucocytes from the recovered patients were incubated with the infecting strain of virus (Port Chalmers), a 49-54% inhibition of chemotaxis was obtained. These findings support the hypothesis that the altered immune responsiveness and increased predisposition to superinfections found frequently in patients with influenza can be due to the ability of the virus to depress monocyte function.

Full Text

Duke Authors

Cited Authors

  • Kleinerman, ES; Snyderman, R; Daniels, CA

Published Date

  • November 29, 1975

Published In

Volume / Issue

  • 2 / 7944

Start / End Page

  • 1063 - 1066

PubMed ID

  • 53552

International Standard Serial Number (ISSN)

  • 0140-6736

Digital Object Identifier (DOI)

  • 10.1016/s0140-6736(75)90432-8


  • eng

Conference Location

  • England