Production of chemotactic factor and lymphotoxin by human leukocytes stimulated with Herpes simplex virus.

Journal Article (Journal Article)

Peripheral blood leukocytes (PBL) of 41 subjects were tested for their ability to be stimulated by herpes simplex virus antigens as measured by [(3)H]thymidine incorporation and lymphokine production (i.e., lymphocyte-derived chemotactic factor and lymphotoxin). The PBL of seronegative subjects failed to respond to viral antigens as measured by stimulation or lymphokine production. In contrast, PBL from seropositive subjects without clinical lesions of herpes labialis were stimulated by herpes simplex virus antigens and produced lymphokines. PBL from seropositive patients with clinical lesions of herpes labialis also produced lymphokines, but [(3)H]thymidine incorporation was slightly depressed. These findings suggest that lymphocytes from patients with a recent herpes simplex virus infection may respond less vigorously to in vitro stimulation by herpes antigens, but our study fails to show any basic defect in the responsiveness of the lymphocytes to account for recurrent herpetic episodes.

Full Text

Duke Authors

Cited Authors

  • Rosenberg, GL; Snyderman, R; Notkins, AL

Published Date

  • July 1, 1974

Published In

Volume / Issue

  • 10 / 1

Start / End Page

  • 111 - 115

PubMed ID

  • 4366917

Pubmed Central ID

  • PMC414965

International Standard Serial Number (ISSN)

  • 0019-9567

Digital Object Identifier (DOI)

  • 10.1128/iai.10.1.111-115.1974


  • eng

Conference Location

  • United States